Thirty-something Annie (Kristen Wiig) has hit a rough patch but finds her life turned completely upside-down when she takes on the Maid of Honor role in her best friend Lillian's (Maya Rudolph) wedding. In way over her head but determined to succeed, Annie leads a hilarious hodgepodge of bridesmaids (Rose Byrne, Melissa McCarthy, Wendi McLendon-Covey and Ellie Kemper) on a wild ride down the road to the big event.