Bronx SIU takes place in the one of the most dangerous boroughs in New York City. It follows the pursuits of a young charismatic homicide detective, Jimmy Blue. Jimmy suffers from post-traumatic stress disorder after the war in Afghanistan and finds himself struggling to juggle his personal life with his demanding job. After a string of homicides, Jimmy is commissioned to lead an elite unit of investigators tasked with solving only the most heinous crimes. Jimmy faces his own demons as well, and tries to function amidst the backdrop of a looming internal affairs investigation into missing funds from a prior drug bust.