Lead Criminalist Horatio Caine (David Caruso) is targeted by adversaries old and new in the fifth season of CSI: Miami. As the danger grows for Caine, he and the rest of his team: Calleigh (Emily Procter), Eric (Adam Rodriguez), Alexx (Khandi Alexander), Ryan (Jonathan Togo), Frank (Rex Linn), and Natalia (Eva La Rue), must go the limit to solve their biggest cases yet.