Nolan Hayes (Walker) arrives at a New Orleans hospital with his pregnant wife, Abigail (Rodriguez), who has gone into early labor. Things quickly spiral out of control when the birth goes tragically wrong and Hurricane Katrina hits, ravaging the hospital and forcing an evacuation. With his baby dependent on a ventilator and no one around to help, Nolan faces one life-and-death decision after another and must fight to keep his daughter alive.