The glamorous Mae West stars as a kept woman who flees to Alaska and the Gold Rush of the 1890s in Klondike Annie. After the beautiful Rose Carlton (West) escapes from the clutches of the wealthy and possessive Chan Lo (Harold Huber), she finds herself on a ship bound for greater pastures. The ships captain, Bull Brackett (Victor McLaglen), instantly falls for Rose but she is distracted by her new cabin mate, Sister Annie Alden (Helen Jerome Eddy). Exchanging philosophies, the unlikely pair develop a meaningful friendship before Sister Annie becomes sick and passes on. In desperation, as Roses past starts to catch up with her, she changes her identity with her deceased friend and is inspired to a new calling. Mae West is at her best as she brings the immortal townspeople to their knees with her unconventional style of evangelism in this spirited tale of divine transformation.