Agent Sean Vetter (Vin Diesel) is a DEA operative fighting the drug wars along the US/Mexican border. After a major player from the Baja Cartel is imprisoned, a new mysterious figure known as Diablo wrests control over the entire operation. But when Vetter's wife is murdered in a botched hit, he and his partner (Larenz Tate) must join forces with the jailed Cartel boss to hunt down the dangerous and elusive new player.