Nana Komatsu dreams of finding happiness and whirlwind romance in the big city. Nana Osaki tirelessly pursues her ambitions of punk rock stardom and worldwide fame. Although these two twenty-somethings might share nothing in common but their first name, a chance meeting on a Tokyo-bound train sets them on a collision course with destiny. As their fates intertwine, they navigate blooming relationships and support one another in their struggles, but it's only a matter of time until the harsh realities of life in metropolitan Tokyo threaten to tear apart everything they've built in the legendary shoujo series NANA.