The life of Chicago architect Bob Rueland (David Duchovny) is turned upside down when his wife, Elizabeth (Joely Richardson), is suddenly killed in a car accident. Her heart is transplanted into Grace Briggs (Minnie Driver) who has suffered from heart disease since childhood and is near death. While Grace is able to move on in her new life and fulfill her dreams of traveling to Italy, Bob remains deeply depressed in his grief. That is until a chance meeting with Grace, who is a waitress at a restaurant he's dining at on a blind date. Bob and Grace begin to date without each other knowing their very intense connection. The romantic comedy RETURN TO ME, directed by and co-starring Bonnie Hunt (JERRY MAGUIRE, THE GREEN MILE), features engaging supporting performances by Carroll O'Connor (TV's ALL IN THE FAMILY, POINT BREAK, KELLY'S HEROES), Robert Loggia (THE JAGGED EDGE, Cable TV's THE SOPRANOS), Joely Richardson (THE PATRIOT, THE GIRL WITH THE DRAGON TATTOO), and David Alan Grier (BEWITCHED, TV's IN LIVING COLOR).