The prize: ending the Apocalypse. The price: Sam's life. Season 5 horrific finale left Dean alone, as Sam descended into Hell. Now a different man, Dean vows to stop hunting and devote himself to building a family with Lisa and her son Ben. Then, mysteriously, Sam reappears, drawing Dean back into the old life. But Sam's a different man too. He's returned without his soul. How the Winchesters confront this greatest challenge yet to their powerful bond is the troubled heart and soul of the profound and thrilling 5-Disc, 22-Episode Season 6. As the brothers struggle to reunite, they must also battle deadly Supernatural forces. Demons. Angels. Vampires. Shapeshifters. And a terrifying new foe called the Mother of All.