After ten years of marriage, Jeff and Nealy Lang (Tobey Maguire and Elizabeth Banks) have an idyllic suburban home... and a relationship on the skids. But, when a family of hungry raccoons ransacks their perfectly manicured backyard, Jeff becomes obsessed with eradicating the pests by any means necessary. Soon the relentless rodents aren't merely uprooting the lawn, but also overturning the Lang's' entire bourgeois existence, as the man-versus-beast battle leads into an absurd mess of infidelity, extortion, organ donation and other assorted mayhem.