Trust the Man features the romantic episodes of two couples: A successful actress (Julianne Moore), her stay at home husband (David Duchovny) her slacker brother (Billy Crudup) and his aspiring novelist girlfriend (Maggie Gyllenhaal). The soundtrack features an array of artists including Libby Johnson, Ben Harper, Rachael Yamagata, Dave's True Story, Chocolate Genius and Leona Naess.