A spoiled heiress with a habit of jilting fiancés (Joan Fontaine) turns her latest getaway into an unforgettable adventure when she ropes in a down-on-his-luck cargo pilot (James Stewart). Together, they embark on a cross-country flight filled with outrageous mishaps, including a fugitive on the run, a pair of love-struck newlyweds, a shipment of lobsters, and a cigar-smoking chimp with a knack for mischief.